Chromosome number change
Aneuploidy
An increase or decrease in the number of an individual chromosome
STEM CELL GENOMIC SCREENING
Stem cell
genomic stability screening
Explore chromosome changes in culture
at the genomic level.
Array CGH-based chromosome copy number analysisArray comparative genomic hybridization
Array Comparative Genomic Hybridization
01 / WHY IT MATTERS
With repeated cell culture,
check for genomic changes.
During long-term culture and passaging, stem cells may develop changes in chromosome number or segmental copy number. Genomic analysis helps characterize cell lines and manage research quality. [1]
Microdeletion
Microdeletion
Loss of a chromosome segment reduces its copy number
Microduplication
Microduplication
An extra chromosome segment increases its copy number
Conceptual diagrams for explanation only. Letters represent hypothetical chromosome segments, not actual results.
02 / ANALYSIS WORKFLOW
From request to results,
the analysis workflow at a glance
The workflow covers sample preparation, fluorescence signal analysis and result review.
Sample preparation & request
Confirm the cell type and culture history, and prepare a sample suited to the analysis objective.
Genomic material preparation
Obtain DNA from the sample and perform whole genome amplification (WGA) if required.
Fluorescent labeling
Label the sample and reference DNA with different fluorophores.
Microarray hybridization
Hybridize the labeled DNA to the array to compare relative amounts at each sequence region.
Scanning & copy number analysis
Read fluorescence signals and analyze gain and loss patterns across chromosome regions.
Result review & reporting
Review detected changes and interpretation limits, then report the results.
The detailed workflow and turnaround time may vary with sample condition and analysis requirements.
- DNA
- Deoxyribonucleic Acid
- WGA
- Whole Genome Amplification
03 / INTERPRETATION
Understanding karyotyping and
genomic copy number analysis
| Comparison | Array CGH | Conventional karyotyping |
|---|---|---|
| Analysis target | Relative DNA copy number | Chromosome number, shape and structure |
| Microdeletions & microduplications | Within the array design coverage | Limited for small changes |
| Balanced rearrangements* | Generally not detected | Some translocations and inversions can be detected |
| Metaphase chromosomes | Not required | Required |
* Changes in chromosome position or orientation without an overall change in copy number.
The two methods can be complementary. Array CGH alone cannot identify all genetic abnormalities or establish cell safety. [2]
REQUEST DOCUMENTS
Analysis request forms
Download and complete both forms below when requesting analysis.
Test request form
Enter the information required for your test request.
Genetic testing consent form
Read the consent form and complete the required fields.
Attach the completed forms to your email.
- Complete both formsComplete the test request form and genetic testing consent form.
- Prepare photographs or scansPhotograph or scan every page of the completed forms. Check that all information is clearly legible.
- Attach & send by emailAttach photographs or scans of both forms to your request email addressed to ginfo@genonlab.com.
Click “Prepare analysis inquiry email” below, then manually attach your files to the email.
Email & contact detailsCONTACT GENonLAB
Request analysis & quotation
Contact us to confirm sample type, quantity, storage, shipping conditions and turnaround time.
Complete the test request and genetic testing consent forms, then attach photographs or scans to your request email.
Include the cell type, analysis objective and requested schedule to help us review your request.
ginfo@genonlab.com02-858-7905
The inquiry button opens your email app. If it does not open, copy the address above and send your inquiry using your preferred email service.
Sources & references
- Tosca et al. Molecular Cytogenetics 8, 30 (2015). Cell culture and genomic changes.
- Agilent. Array CGH workshop (2016). Analysis principles, detection scope and limitations.
- Thermo Fisher Scientific. The A to Z of microarrays. Analysis workflow references.
Genomic analysis for stem cell research · September 2026